My research team is dedicated to obtaining new insight into protein structure, function and interactions by means of mass spectrometry.
From our initial experiments in which we used mass spectrometry to study folding of individual proteins, we have developed this approach to study interactions with cofactors, nucleic acids and with other proteins.
Specifically, we focus on the unique insights that can be gained by applying this gas phase structural biology approach to heterogeneous and dynamic protein complexes.
Recently, these advantages of using this approach have come to the fore with the discovery that it is possible to release protein complexes from detergent micelles in the gas phase of the mass spectrometer.
This is leading to new information, not only on the location and binding of lipids and other small molecules, but also their effects on function.