Group

Working Together

Our research requires the coming together of many different disciplines to understand structure and function relationships of proteins.

Typically, our group comprises researchers with backgrounds from chemistry, physics, computer science, structural and molecular biology, as well as scientists skilled in proteomics and lipidomics and those interested in developing instrumentation.

Bringing together these skillsets enables us to tackle challenging biological questions.  For example, how are receptors, ion channels and transporters regulated and controlled?

Jani Reddy Bolla

Contact information: jani.bolla@chem.ox.ac.uk

Jani employs native mass spectrometry techniques and X-ray crystallography to characterise the multiprotein machineries involved in peptidoglycan and outer membrane biogenesis in Gram-negative bacteria.  The goal of his research is to provide useful information for the development of more effective vaccines as well as targets for new drug design against bacterial infections. A full list of Jani's publications can be found here

Jani studied chemical sciences at Pondicherry University, India and then moved to Iowa State University for his doctoral studies under the supervision of Prof. Edward Yu.  He joined the Robinson group in 2015.  

Tarick J. El-Baba

Contact information: tarick.el-baba@chem.ox.ac.uk

Tarick’s research is focused on characterising membrane proteins involved with multidrug resistance using native mass spectrometry, proteomics, and molecular biology. His research aims to identify the mechanisms involved with drug recognition, efflux pump assembly, and substrate translocation. Tarick’s background is primarily in mass spectrometry instrument development.

Tarick obtained his BSc in Chemistry from Wayne State University in Detroit, Michigan and his PhD from Indiana University where he developed new ion mobility-mass spectrometry instruments to study protein folding in the group of Prof. David E. Clemmer. He joined the Robinson lab in 2019 as a Royal Society Newton International Fellow. A complete list of his publications can be found here.

Corinne Lutomski

Contact information: corinne.lutomski@chem.ox.ac.uk

Corinne’s background is in the development of new techniques in mass spectrometry to study large protein complexes. Her research aims to further develop detergent-free methods to study GPCRs in the context of their native environments and investigate the modulating effects of lipids on structure, dynamics, and ligand binding. A full list of Corinne’s publications can be found here. (https://scholar.google.com/citations?user=ajsWw90AAAAJ&hl=en)

Corinne received a BSc in Chemistry at Wayne State University in Detroit, Michigan, USA. She then completed her PhD at Indiana University under the supervision of Prof. Martin Jarrold. Corinne joined the Robinson group as a Marie Curie Fellow in 2019. 

Abraham Olusegun Oluwole

Contact information: abraham.oluwole@chem.ox.ac.uk

Abraham uses lipid/polymer nanodiscs as a platform to capture membrane proteins together with their endogenous ligands for analysis by native mass spectrometry. This may assist our understanding of native structure and function of membrane proteins in a more native-like lipid-bilayer environment.

Abraham studied Chemistry at Ladoke Akintola University of Technology, Ogbomoso and at the University of Ibadan, Nigeria. During his PhD, he investigated the use of lipid/polymer nanodiscs in biophysical characterisation of membrane proteins at the University of Kaiserslautern, Germany under the supervision of Prof. Dr. Sandro Keller. He joined the Robinson group in 2018.

Ritu Raj

Contact information: ritu.raj@chem.ox.ac.uk

Ritu’s background is in chemical biology, especially protein chemistry and mass spectrometry based-proteomics. His current research  focuses on combining synthetic biology and native mass spectrometry approaches to elucidate the modulation of membrane protein structure and function upon lipidation. He is also developing chemical approaches to analyse specific membrane protein-lipid interactions which are difficult to observe using other biophysical methods.

Ritu earned his BS-MS degree in Chemical Sciences from IISER Kolkata, India and then moved to the University of Oxford for his doctoral studies on a Felix Scholarship. He joined the Robinson group in 2018 and is currently a Junior Research Fellow at the Somerville College.

Haiping Tang

Contact information: haiping.tang@chem.ox.ac.uk

Haiping’ research aims to further develop detergent-free methods to study complexes within their native environment and thus probe the effects of drugs in direct contact with some key membrane targets, such as solute carriers and rhomboids.

Haiping graduated from Jilin University, China and obtained her PhD from Tsinghua University, China. She joined the Robinson group in 2018.

Leonhard Urner                       

Contact information: leonhard.urner@chem.ox.ac.uk

Leo develops new detergent and polymer platforms that facilitate not only the structural analysis of membrane proteins but also the analysis of proteome-lipidome interactions. He uses mass spectrometry and related techniques to study the role of the lipidome for the structure and function of membrane proteins.

Leo studied chemistry at the Freie Universität Berlin. He obtained his doctoral degree under the supervision of Prof. Kevin Pagel and in co-operation with Prof. Rainer Haag. He joined the Robinson group in 2018. 

Di Wu

Contact information: di.wu2@chem.ox.ac.uk

Di is interested in understanding lipid micro-environment of membrane proteins and dynamic protein post-translational modifications by integrative mass spectrometry based approaches, including native MS, metabolomics, proteomics and biochemistry. He is developing new methods for quantitative analysis of membrane ion channel-lipid interaction. He is also using high resolution native MS to elucidate the importance of glycosylation in protein-protein/drug interactions.

Di obtained his BSc and MSc from Wuhan University, China and completed his PhD at the University of Dundee.  He joined the Robinson group in 2015.

Siyun Chen   

Contact information: siyun.chen@chem.ox.ac.uk

DPhil title: Protein assemblies ejected from membranes based on native mass spectrometry

Siyun is using native mass spectrometry techniques to investigate the structure and regulation of protein assemblies ejected from membranes. She is currently studying the role of lipids on the structure and function of membrane proteins such as GPCRs. The elucidation of the molecular mechanism of these proteins may provide useful information for the design of novel drugs.

Siyun studied Applied Chemistry at East China University of Science and Technology and specialized in ion mobility mass spectrometry at Peking University, China.  She joined the Robinson group for her DPhil in 2019.

Xingyu Qiu (Philip)

Contact information: xingyu.qiu@exeter.ox.ac.uk

DPhil title: Investigating the GPCR activation process through mass spectrometry related methods

Philip is studying the GPCR activation mechanism through mass spectrometry related methods including HDX, native MS and ion mobility. Exploration of GPCR-ligand interaction during the receptor activation will promote the development of drug targeting on GPCRs.

Philip studied Chemistry at University of Oxford and joined the Robinson group for his DPhil studies in 2018.

Daniel Questschlich

Contact information: Daniel.quetschlich@dtc.ox.ac.uk

DPhil title: Integrating Molecular Dynamics Simulations and Native Mass Spectrometry to Investigate Protein-Lipid Interactions in Membrane transporters and Receptors

Daniel is developing an integrated approach using native mass spectrometry and molecular dynamics simulations to understand the regulatory role of lipids in membrane protein oligomerisation.

Daniel studied physics with a specialisation in biophysics at the University of Göttingen, Germany.   He commenced his DPhil in October 2017 jointly in the Robinson laboratory and the Stansfeld/Sansom laboratories in the Structural Bioinformatics and Computational Biochemistry Unit.

 

The Group is fortunate to have two experienced technical staff, Dr. Andrew Dolan and Dr. Victoria Cullen.  Andy, our technical laboratory manager is responsible for the maintenance and smooth running of the current instruments and Vicky ensures the day-to-day smooth running of all aspects of the laboratory.

The Group is also supported by a Project Coordinator, Anne Gough.

 

Timothy Allison

Lecturer

University of Canterbury - New Zealand

Nelson Barrera

Assistant Professor

University of Chile - Chile

Cherine Bechara

Assistant Professor

University of Montpelier - France

Justin Benesch

Associate Professor

University of Oxford - United Kingdom

Antoni Borysik

Lecturer in Analytical Chemistry

King’s College, London - United Kingdom

Matt Bush

Professor

University of Washington - USA

Kallol Gupta

Assistant Professor

Yale School of Medicine - USA

Zoe Hall

Lecturer

Imperial College, London - United Kingdom

Leopold Ilag

Associate Professor

Stockholm University - Sweden

Arthur Laganowsky

Assistant Professor

Texas A &  M University - USA

Michael Landreh

Assistant Professor

Karolinska Institute - Sweden

Julien Marcoux

Researcher

Institute of Pharmacology & Structural Biology, Toulouse - France

Michael Marty

Assistant Professor

University of Arizona - USA

Shahid Mehmood

Senior Research Scientist

The Francis Crick Institute, London - United Kingdom

Nina Morgner

Jun. Professor

Goethe University,Frankfurt - Germany

Kevin Pagel

Professor

Free University of Berlin - Germany

Argyris Politis

Senior Lecturer in Chemical Systems Biology

King’s College, London - United Kingdom

Tara Pukala

Associate Professor

The University of Adelaide - Australia

Eamonn Reading

Lecturer in Chemistry

King's College, London - United Kingdom

Brandon Ruotolo

Professor

University of Michigan - USA

Carla Schmidt

Assistant Professor

Martin Luther University - Germany 

Michal Sharon

Professor

Weizmann Institute of Science - Israel

Frank Sobott

Professor

University of Leeds - United Kingdom

Yao Zhongping

Associate Professor

Hong Kong Polytechnic University - Hong Kong

Min Zhou

Professor

Nanjing University of Science

& Technology - China

   

 

Group Christmas Dinner 2017

 

Group Christmas Dinner 2018
 
group christmas dinner 2018 1
 
 
 
 

 

Group Christmas Dinner 2019

 

Group Summer BBQ 2017

 

Group Summer BBQ 2018

 

Group Summer BBQ 2019