Our research uses state-of-the-art mass spectrometry to study proteins, primarily membrane proteins, in different environments.
To do this we recreate as closely as possible the lipid environment and seek to uncover interactions between proteins and their cofactors.
These cofactors are often difficult to define using established structural biology approaches but provide vital clues as to the tasks performed by proteins.
Our research has defined key roles for cofactors in mediating protein interfaces, in facilitating transporter function and in controlling antibiotic resistance mechanisms.
Researchers in our laboratory can acquire many skills including: mass spectrometry, ‘omics techniques’, protein expression, molecular modelling and hydrogen deuterium exchange methods.
